One of the most debated topics in cardiovascular medicine iswhether C-reactive protein (CRP), a component of the acute-phaseresponse, is a causal factor in the pathogenesis of atherosclerosis.1,2If it is, the implications could be far-reaching and includenew approaches for the prevention and treatment of myocardialinfarction and stroke.3 Support for a role of CRP in the pathogenesisof atherosclerosis comes largely from epidemiologic studiesthat have consistently observed an association between elevatedplasma CRP levels and cardiovascular events.1,4,5 The statisticalstrength of such associations is at least as robust as thatof established risk factors such as . . . [Full Text of this Article]
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From the Medizinische Klinik II, Universität zu Lübeck, Lübeck, Germany (H.S.); and the Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (N.J.S.).
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