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Review Article
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Volume 359:2025-2033 November 6, 2008 Number 19
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Venous Thromboembolic Disease and Pregnancy
Paul E. Marik, M.D., and Lauren A. Plante, M.D., M.P.H.

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Pulmonary embolism and deep-vein thrombosis are the two components of a single disease called venous thromboembolism. Approximately 30% of apparently isolated episodes of pulmonary embolism are associated with silent deep-vein thrombosis, and in patients presenting with symptoms of deep-vein thrombosis, the frequency of silent pulmonary embolism ranges from 40 to 50%.1,2 Venous thromboembolism is both more common and more complex to diagnose in patients who are pregnant than in those who are not pregnant. The incidence of venous thromboembolism is estimated at 0.76 to 1.72 per 1000 pregnancies, which is four times as great as the risk in the nonpregnant . . . [Full Text of this Article]

Risk Factors for Venous Thromboembolism

Heritable Thrombophilia and Venous Thromboembolism

Diagnosis of Venous Thromboembolism

Management of Venous Thromboembolism during Pregnancy

Anticoagulant Therapy during Labor and Delivery

Thrombolytic Therapy

Management of Pulmonary Embolism in Late Pregnancy and Labor

Thromboprophylaxis during Pregnancy and the Puerperium

Thromboprophylaxis after Cesarean Section


Source Information

From the Division of Pulmonary and Critical Care Medicine (P.E.M.), the Department of Obstetrics and Gynecology (L.A.P.), and the Department of Anesthesiology (L.A.P.), Thomas Jefferson University, Philadelphia.

Address reprint requests to Dr. Marik at Pulmonary and Critical Care Medicine, Thomas Jefferson University, 834 Walnut St., Suite 650, Philadelphia, PA, 19107, or at paul.marik@jefferson.edu.


Related Letters:

Venous Thromboembolic Disease and Pregnancy
Larson L., Miller M., Mehta N., Dholakia S., de Mendonca N., Hayes M., Bourjeily G., Rosene-Montella K., Hoftman N., Marik P. E., Plante L. A.
Extract | Full Text | PDF  
N Engl J Med 2009; 360:638-640, Feb 5, 2009. Correspondence

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