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Editorial
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Volume 359:2280-2282 November 20, 2008 Number 21
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Expanding the Orbit of Primary Prevention — Moving beyond JUPITER
Mark A. Hlatky, M.D.

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 by Kritek, P.

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 by Ridker, P. M
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Editor's note: We invite readers to submit comments on the JUPITER trial in a new interactive feature, Clinical Directions – The JUPITER Trial: Will You Change Your Practice? Commenting closes November 26, 2008.

The aphorism "prevention is better than cure" makes perfect sense when applied to healthy habits such as following a sensible diet, maintaining an ideal body weight, exercising regularly, and not smoking. But increasingly, prevention of cardiovascular disease includes drug therapy, particularly statins to lower cholesterol levels. Statins were first tested in subjects at high risk for coronary events, and the limits of treatment have subsequently been expanded to include persons at progressively lower risk.1 The results of the Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER; ClinicalTrials.gov number, NCT00239681 [ClinicalTrials.gov] ), reported by Ridker . . . [Full Text of this Article]


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This article (10.1056/NEJMe0808320) was published at www.nejm.org on November 9, 2008.

From the Stanford University School of Medicine, Stanford, CA.


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