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Previous Volume 359:2492-2494 December 4, 2008 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Proteinuria is a cardinal sign of kidney disease, a prognostic marker, and an independent risk factor for cardiovascular disease. It is the earliest sign of renal complications of diabetes, obesity, and the metabolic syndrome. Therapy to reduce or prevent proteinuria is therefore highly desirable. Several advances^1,2,3,4,5 have helped to refine the targets for such therapy, and — as the recent study by Faul and colleagues¹ shows — these advances have delivered some surprises.

Proteinuria occurs when the permeability of the glomerular capillary wall is increased. This increase may occur because of inflammatory injury in systemic autoimmune diseases such as lupus . . . [Full Text of this Article]

Source Information

From the Academic Renal Unit, University of Bristol and Southmead Hospital — both in Bristol, United Kingdom.

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