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Previous Volume 359:2720-2722 December 18, 2008 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Ovarian cancer is the leading cause of deaths from gynecologic cancer, and although there are nomograms that use pathological variables to predict outcome for advanced-stage disease,¹ few if any molecular mechanisms that accurately predict outcome and can potentially guide therapy have been identified. The article by Merritt et al.² in this issue of the Journal provides evidence for a simple mechanism, based on the biologic characteristics of microRNAs (miRNAs), for formulating a prognosis and potentially guiding therapy in ovarian cancer.

The past decade has heralded in a new era in the understanding of gene regulation in diseases such as cancer. . . . [Full Text of this Article]

Source Information

From the Department of Molecular, Cellular, and Developmental Biology (F.J.S.) and the Department of Therapeutic Radiology (J.B.W.), Yale University, New Haven, CT.

This article has been cited by other articles:

• Fabbri, M., Valeri, N., Calin, G. A. (2009). MicroRNAs and genomic variations: from Proteus tricks to Prometheus gift. Carcinogenesis 30: 912-917 [Abstract] [Full Text]