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Previous Volume 359:2729-2731 December 18, 2008 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their letter to the editor, Westermark and colleagues (Aug. 28 issue)¹ report on their identification of amyloid in 43% of intrahepatically transplanted islets on postmortem examination of a recipient with type 1 diabetes. Amyloid is composed of amylin (islet amyloid polypeptide [IAPP]) that is cosecreted from the beta cell with insulin but normally is inhibited from forming amyloid by appropriate proportions of insulin and other factors in the beta cell.^2,3 Proportions of insulin and amylin within the beta cell are best estimated in vivo following secretion after acute stimulation.⁴ To determine whether insulin and amylin are . . . [Full Text of this Article]

Related Letters:

Widespread Amyloid Deposition in Transplanted Human Pancreatic Islets
Westermark G. T., Westermark P., Berne C., Korsgren O., the Nordic Network for Clinical Islet Transplantation
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N Engl J Med 2008; 359:977-979, Aug 28, 2008. Correspondence

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