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Correspondence
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Volume 359:320-321 July 17, 2008 Number 3
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Resolution of Non–Small-Cell Lung Cancer after Withdrawal of Anti-TNF Therapy

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To the Editor: We report the development of locally advanced non–small-cell lung cancer (tumor–node–metastasis [TNM] stage T4N2M0) in a 69-year-old woman with Crohn's colitis. Her condition had been diagnosed in 2000 and had required treatment with methotrexate (from 2003 to the present), together with anti–tumor necrosis factor (TNF) therapies — initially, episodic infliximab (from 2000 to 2004) and thereafter, maintenance adalimumab, until the tumor was diagnosed in June 2006. Remarkably, the tumor expressed TNF receptors and underwent regression and sustained remission on withdrawal of anti-TNF therapy, with no other therapeutic intervention.

In 1999, the patient, a former smoker (35 pack-years), . . . [Full Text of this Article]



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