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Volume 359:651-653 August 7, 2008 Number 6
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Cytogenetically Normal Acute Myeloid Leukemia

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 by Schlenk, R. F.
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To the Editor: Schlenk and colleagues (May 1 issue)1 found that patients who have cytogenetically normal acute myeloid leukemia (AML) with a genotype other than mutant NPM1 (nucleophosmin gene) without FLT3-ITDs (fms-related tyrosine kinase 3 gene internal tandem duplications) benefit from transplantation of hematopoietic stem cells from HLA-matched related donors. The authors assigned patients with an identified donor to a donor group and the other patients to a no-donor group. This method has been used in a meta-analysis involving 3103 patients.2 However, the donor versus no-donor method must be restricted to HLA-typed patients with a sibling because the two . . . [Full Text of this Article]


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