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Previous Volume 360:80-82 January 1, 2009 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Osteoclasts are multinucleated cells responsible for the resorption of bone matrix. During the development and growth of a human, they ensure proper contouring of the bones and extension of the medullary spaces to provide for hematopoiesis. In the adult skeleton, osteoclasts ensure remodeling of the bone matrix by means of a process of internal turnover. Skeletal homeostasis is achieved by focal osteoclast-mediated degradation of the bone matrix and osteoblast-mediated formation of new bone matrix without compromising the overall architecture and anatomy of bones. Under ideal conditions, the amount of new bone equals the amount resorbed, with no net change in . . . [Full Text of this Article]

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From the Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston.

Related Letters:

Giant Osteoclast Formation and Long-Term Oral Bisphosphonate Therapy
Jobke B., Roos J. C., Cox T. M., Weinstein R. S., Roberson P. K., Manolagas S. C.
Extract | Full Text | PDF  
N Engl J Med 2009; 360:1676-1678, Apr 16, 2009. Correspondence

This article has been cited by other articles:

• Jobke, B., Roos, J. C., Cox, T. M., Weinstein, R. S., Roberson, P. K., Manolagas, S. C. (2009). Giant Osteoclast Formation and Long-Term Oral Bisphosphonate Therapy. NEJM 360: 1676-1678 [Full Text]