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Previous Volume 360:85-86 January 1, 2009 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their article on intensive lipid lowering, Rossebø et al. (Sept. 25 issue)¹ report that therapy with simvastatin and ezetimibe did not reduce aortic-valve disease and calcifications in patients with mild-to-moderate asymptomatic aortic stenosis. In an accompanying editorial, Otto² accurately states that "calcific aortic stenosis is not atherosclerosis." However, she does not take advantage of this opportunity to develop the conclusion further. Indeed, in a variety of murine models, vascular calcification develops in the absence of overt atherosclerosis.³ Furthermore, osteoprotegerin has been reported to inhibit vascular calcification without affecting atherosclerosis,³ and therapy with bone morphogenetic protein 7 . . . [Full Text of this Article]

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