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Volume 360:1038-1042 March 5, 2009 Number 10
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Rosuvastatin in Patients with Elevated C-Reactive Protein

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by Ridker, P. M
To the Editor: Ridker et al. (Nov. 20 issue) report the results of Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER),1 which showed that rosuvastatin significantly reduced cardiovascular events in patients with elevated levels of C-reactive protein. However, broad application of their results in primary prevention is premature, since the baseline therapy that many patients in the study were receiving did not meet existing standards. Although about 50% of the patients had intermediate Framingham risk scores, which would have qualified such men (and possibly women) for aspirin therapy,2,3 only 16.6% of the patients were . . . [Full Text of this Article]



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