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Volume 360:1150-1151 March 12, 2009 Number 11
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Dicer and Drosha in Ovarian Cancer

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by Merritt, W. M.
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To the Editor: Merritt et al. (Dec. 18 issue)1 report finding a relation between prognosis and the expression of Dicer and Drosha in women with ovarian carcinoma of unstated histologic subtype. The histologically defined subtypes of ovarian carcinoma (high-grade serous, clear cell, endometrioid, mucinous, and low-grade serous) are distinct diseases that can be reproducibly diagnosed2 and that vary with respect to characteristics of the precursor lesions, the genetic events during oncogenesis,3 outcome,2,4 and response to chemotherapy.4 These subtypes have distinct biomarker-expression profiles.5 In cohorts of patients with ovarian carcinoma consisting of a mixture of subtypes, biomarkers preferentially expressed by specific . . . [Full Text of this Article]



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