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Correspondence
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Volume 360:1253-1254 March 19, 2009 Number 12
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RTS,S/AS01E Vaccine against Malaria

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by Bejon, P.
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To the Editor: The results of the trial reported by Bejon et al. (Dec. 11 issue),1 in which the malaria vaccine RTS,S/AS01E was administered to children in Kilifi, Kenya, and Korogwe, Tanzania, are impressive. However, there are methodologic issues in the measurement of protective efficacy in sites where the transmission of malaria is falling. In such areas, transmission becomes overdispersed, and measuring protective efficacy against malaria over short periods may be inappropriate.2 For example, the high protective efficacy of intermittent preventive treatment for malaria in infants that was observed in the first clinical trial in Tanzania was probably exaggerated by . . . [Full Text of this Article]



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