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Volume 360:1254-1255 March 19, 2009 Number 12
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Antimalarial Therapies in Children from Papua New Guinea

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by Karunajeewa, H. A.
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To the Editor: In their article on antimalarial combination therapies, Karunajeewa et al. (Dec. 11 issue)1 conclude that artemether–lumefantrine has more favorable efficacy than dihydroartemisinin–piperaquine, even though fat was given with the treatment only in the artemether–lumefantrine group and there was no significant difference in the primary end point. Their per-protocol analysis with a high dropout rate from a small sample results in overestimation of the risk of treatment failure and wide 95% confidence intervals (6.4% to 20.0%). We reanalyzed data from 981 children younger than 5 years of age who were treated with dihydroartemisinin–piperaquine in seven clinical trials in . . . [Full Text of this Article]



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