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Correspondence
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Volume 360:1255-1256 March 19, 2009 Number 12
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Smoking Exposure, 17q21 Variants, and Early-Onset Asthma

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by Bouzigon, E.
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To the Editor: Bouzigon et al. (Nov. 6 issue)1 report that single-nucleotide polymorphisms (SNPs) in the 17q21 region are associated with early-onset asthma in subjects exposed to environmental tobacco smoke. One would predict that environmental factors would have a greater effect in late-onset disease than in early-onset disease. We wonder whether the authors can provide data on SNPs that regulate susceptibility to late-onset asthma when there is passive exposure to tobacco smoke or when the subject is a smoker.


Hiroyuki Morita, M.D., Ph.D.
Ryozo Nagai, M.D., Ph.D.
University of Tokyo
Tokyo 113-8655, Japan
hmrt-tky@umin.net

  1. Bouzigon E, Corda E, Aschard H, et al. Effect of 17q21 variants and smoking exposure in early-onset asthma. N Engl J Med 2008;359:1985-1994. [Free Full Text]
 
The authors reply: We have shown . . . [Full Text of this Article]



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