Three landmark randomized, controlled trials conducted in SouthAfrica, Uganda, and Kenya from 2005 through 2007 demonstratedthat adult male circumcision reduced the acquisition of humanimmunodeficiency virus (HIV) by 50 to 60%.1,2,3 Complicationsassociated with the procedure were rare and almost uniformlyminor.4 These findings were largely consistent with those ofobservational and ecologic studies in which adult male circumcisionwas associated with a lower HIV risk at both individual andpopulation levels,5 and mathematical models suggest that widespreadcircumcision could substantially reduce the HIV epidemic inhigh-prevalence heterosexual populations.6 In 2007, the WorldHealth Organization and the United . . . [Full Text of this Article]
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From the Center for AIDS and STD (M.R.G.) and the Departments of Global Health and Medicine (J.N.W.), University of Washington; Public Health–Seattle and King County STD Control Program (M.R.G.); and the Fred Hutchinson Cancer Research Center (J.N.W.) — all in Seattle.
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