The New England Journal of Medicine
e-mail icon  FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |    Advanced Search
Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe
 
Correspondence
PreviousPrevious
Volume 360:1572-1574 April 9, 2009 Number 15
NextNext

Case 3-2009: A 9-Month-Old Boy with Seizures

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

 Sign up for free e-toc
 

This Article
-Full Text
- PDF
-PDA Full Text
-Purchase this article

Tools and Services
-Add to Personal Archive
-Add to Citation Manager
-Notify a Friend
-E-mail When Cited
-E-mail When Letters Appear

More Information
-Related Article
by Holick, M. F.
-PubMed Citation
To the Editor: In the Case Record of a patient with hypocalcemic seizures due to vitamin D deficiency, discussed by Holick et al. (Jan. 22 issue),1 it is surprising to note that in spite of these seizures, he was treated with fosphenytoin twice. Phenytoin accelerates metabolism of 1,25-dihydroxyvitamin D because of induction of the cytochrome P-450 system, and it will lead to exacerbation of hypocalcemia and seizures.2,3,4 Phenytoin also is implicated in end-organ resistance to the biologic effects of 1,25-dihydroxyvitamin D.4


Ajit Singh Kashyap, M.D.
Command Hospital
Lucknow 226 002, India
kashyapajits@gmail.com


Kudip Parkash Anand, M.D.
Pravara Institute of Medical . . . [Full Text of this Article]



HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  TERMS OF USE  |  HELP  |  beta.nejm.org

Comments and questions? Please contact us.

The New England Journal of Medicine is owned, published, and copyrighted © 2009 Massachusetts Medical Society. All rights reserved.