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Previous Volume 360:1646-1654 April 16, 2009 Number 16 Next

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In 1976, the noted human geneticist James Neel titled a book chapter "Diabetes Mellitus: A Geneticist's Nightmare."¹ Over the past 30 years, however, the phenotypic and genetic heterogeneity of diabetes has been painstakingly teased apart to reveal a family of disorders that are all characterized by the disruption of glucose homeostasis but that have fundamentally different causes. Recently, the availability of detailed information on the structure and variation of the human genome and of new high-throughput techniques for exploiting these data has geneticists dreaming of unraveling the genetic complexity that underlies these disorders. This review focuses on type 1 diabetes . . . [Full Text of this Article]

Genetic Studies

Genetic Linkage Studies

Candidate-Gene Association Studies

Genomewide Association Studies

Disease Prediction

Future Genetic Studies

Diabetes and Personalized Medicine

Conclusions

Source Information

From the Center for Public Health Genomics (P.C., S.S.R.) and the Departments of Biochemistry and Molecular Genetics (P.C.) and Public Health Sciences (S.S.R.), University of Virginia, Charlottesville; and the Diabetes Research Program, Benaroya Research Institute, Seattle (G.T.N.).

Address reprint requests to Dr. Concannon at the Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, or at patcon@virginia.edu.

Related Letters:

Genetics of Type 1A Diabetes
Sepe V., Loviselli A., Bottazzo G. F.
Extract | Full Text | PDF  
N Engl J Med 2009; 361:211, Jul 9, 2009. Correspondence

This article has been cited by other articles:

• Sepe, V., Loviselli, A., Bottazzo, G. F. (2009). Genetics of Type 1A Diabetes. NEJM 361: 211-211 [Full Text]