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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the author's clinical recommendations.
A 65-year-old woman with osteoarthritis of her right knee is referred by her primary care physician for orthopedic consultation. She is healthy except for some well-controlled hypertension. She is 5 ft 5 in. tall (165 cm) and weighs 160
The Clinical Problem
Pathophysiology and the Effect of Therapy
Clinical Evidence
Clinical Use
Adverse Effects
Areas of Uncertainty
Guidelines
Recommendations
Source Information
From the Department of Orthopedics and Sports Medicine, University of Washington School of Medicine, Seattle.
Address reprint requests to Dr. Leopold at the Department of Orthopedics and Sports Medicine, University of Washington School of Medicine, Box 356500, Seattle, WA 98195, or at leopold@u.washington.edu.
Related Letters:
Minimally Invasive Total Knee Arthroplasty
Kashyap A. S., Anand K. P., Kashyap S., Moneypenny M. J., Mercer S. J., Longo U. G., Maffulli N., Denaro V., Leopold S. S.
Extract |
Full Text |
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N Engl J Med 2009;
361:633-634, Aug 6, 2009.
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