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Clinical Implications of Basic Research
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Volume 360:1785-1786 April 23, 2009 Number 17
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Crohn's Disease, Autophagy, and the Paneth Cell
Daniel J. Klionsky, Ph.D.

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Because of its very nature, the gastrointestinal tract is potentially subject to inflammation and infection. Much of its surface is designed to be highly exposed and absorptive, yet it faces a tremendous microbial population. Therefore, it is not surprising that various gastrointestinal disorders are linked to microbial infection or toxins. For example, peptic ulcers, affecting approximately 10% of the population in the United States, are caused in part by infection with Helicobacter pylori. Accordingly, treatment for this type of ulcer includes antibiotics.

Unfortunately, less success has been achieved in managing another often debilitating disorder, Crohn's disease, an inflammatory disease . . . [Full Text of this Article]


Source Information

From the Life Sciences Institute, University of Michigan, Ann Arbor.

This article (10.1056/NEJMcibr0810347) was published at NEJM.org on April 15, 2009.




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