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Volume 360:2251-2256 May 21, 2009 Number 21
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Geographic Atrophy in Age-Related Macular Degeneration and TLR3

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by Yang, Z.
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To the Editor: Yang et al. (Oct. 2 issue)1 describe the association between a variant of the toll-like receptor 3 gene (TLR3) and protection from geographic atrophy, a major cause of blindness. They also show that the TLR3 genotype affects the sensitivity of human retinal pigment epithelial cells and the retinal pigment epithelium of mice to the proapoptotic effects of long double-stranded RNA (dsRNA), a recognized ligand of TLR3. The dsRNA that they used in these experiments is roughly 100 times the length of small interfering RNA (siRNA) molecules, and yet they conclude that the "results suggest a . . . [Full Text of this Article]



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