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Clinical Implications of Basic Research
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Volume 360:2471-2473 June 4, 2009 Number 23
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The Granuloma in Tuberculosis — Friend or Foe?
Eric J. Rubin, M.D., Ph.D.

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Granulomas are cellular aggregates that are the pathologic hallmarks of tuberculosis. These chronic inflammatory lesions have long been considered to be necessary for containment of infection. A recent study by Davis and Ramakrishnan,1 however, suggests that granulomas may help to promote infection, rather than simply contain it.

The vast majority of persons infected with Mycobacterium tuberculosis remain asymptomatic for life; at least 90% of infected adults never become ill. What is the basis for resistance to tuberculosis? The high rates of clinical tuberculosis among persons infected with the human immunodeficiency virus and also among persons receiving cytotoxic therapy point to . . . [Full Text of this Article]


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From the Harvard School of Public Health, Harvard University, Boston.



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