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Volume 360:302-303 January 15, 2009 Number 3
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Telmisartan for Prevention of Cardiovascular Events

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 by Yusuf, S.
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To the Editor: We have eagerly awaited the results of the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) Study (Sept. 18 issue),1 since a significant benefit of angiotensin-receptor blockers (ARBs) was anticipated based on the findings of several other groups (Losartan Intervention for Endpoint Reduction in Hypertension [LIFE],2 Morbidity and Mortality after Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention [MOSES],3 and Study on Cognition and Prognosis in the Elderly [SCOPE]).4 It was very disappointing to see that telmisartan therapy failed to meet the primary end point — a significant reduction in the rate of recurrent stroke. Furthermore, it . . . [Full Text of this Article]




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