The New England Journal of Medicine
e-mail icon  FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |    Advanced Search
Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe
 
Correspondence
PreviousPrevious
Volume 360:304 January 15, 2009 Number 3
NextNext

SLCO1B1 Variants and Statin-Induced Myopathy

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

 Sign up for free e-toc
 

This Article
-Full Text
- PDF
-PDA Full Text
-Purchase this article

Tools and Services
-Add to Personal Archive
-Add to Citation Manager
-Notify a Friend
-E-mail When Cited
-E-mail When Letters Appear

More Information
-Related Article
by The SEARCH Collaborative Group
-PubMed Citation
To the Editor: Investigators in the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group found one single-nucleotide polymorphism (SNP) in the SLCO1B1 gene that was significantly associated with the risk of development of statin-induced myopathy (P=4x10–9) (Aug. 21 issue).1 The study was performed in patients with a history of myocardial infarction taking a high dose (80 mg) of simvastatin.

The investigators evaluated other SNPs that have been reported elsewhere as having an association with statin myopathy but could not confirm any significant association in these cases. In our investigation of mutations . . . [Full Text of this Article]



HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  TERMS OF USE  |  HELP  |  beta.nejm.org

Comments and questions? Please contact us.

The New England Journal of Medicine is owned, published, and copyrighted © 2009 Massachusetts Medical Society. All rights reserved.