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Previous Volume 360:606-614 February 5, 2009 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.

A 30-year-old woman presents with a history of no menses since she stopped taking oral contraceptives 6 months ago in order to conceive. She had undergone puberty that was normal in both timing and development, with menarche at 12 years of age. At 18 years of age, she started taking oral contraceptives for irregular menses. She reports stress at work. Her weight . . . [Full Text of this Article]

The Clinical Problem

Strategies and Evidence

Evaluation

Management

            Emotional Health

            Hormone-Replacement Therapy

            Maintaining Bone Health

            Associated Disorders

            Family Planning

Areas of Uncertainty

Guidelines

Conclusions and Recommendations

Source Information

From the Integrative Reproductive Medicine Unit, Intramural Research Program on Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.

An audio version of this article is available at NEJM.org.

Address reprint requests to Dr. Nelson at the Integrative Reproductive Medicine Unit, NICHD–Intramural Research Program on Reproductive and Adult Endocrinology, CRC, Rm. 1-3330, 10 Center Dr., MSC-1103, Bethesda, MD 20892, or at lawrence_nelson@nih.gov.

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