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Richard Kradin, as he explains in the acknowledgements section of his book, sets out to develop "an explanatory model for the placebo response," with a particular interest in mind–body physiology and the possible mechanisms of the response — meaning beneficial responses to the fact of treatment, rather than to the treatment itself. Kradin does indeed describe in detail various beliefs about and explanations of placebo responses. One difficulty in attempts to explain and analyze placebo effects, as Kradin recognizes at least some of the time, is that the response is not measured in clinical trials. What we measure is the
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