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Clinical Implications of Basic Research
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Volume 360:726-727 February 12, 2009 Number 7
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Inflammatory Bowel Disease, Stress, and the Endoplasmic Reticulum
Hans Clevers, M.D., Ph.D.

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The causes of Crohn's disease and ulcerative colitis are poorly understood, despite having been defined many decades ago on the basis of their clinical manifestations. Experiments involving transgenic mice and genomewide association studies involving patients have independently provided glimpses into the complexity of the genetic causes of these disorders. A recent study described by Kaser and colleagues1 combines experimental and genetic approaches to build a compelling case implicating the unfolded-protein response as a culprit in inflammatory bowel disease.

Stress in the endoplasmic reticulum is caused by the accumulation of unfolded nascent proteins in the lumen under adverse cellular conditions. This . . . [Full Text of this Article]


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From the Hubrecht Institute, Utrecht, the Netherlands.



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