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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the author's clinical recommendations.
A 45-year-old man was rescued from his burning house. Firefighters removed his smoldering clothes and initiated intravenous access, pulse oximetry, and electrocardiographic monitoring. An endotracheal tube was inserted, and ventilation with 100% oxygen was initiated for presumed airway instability
The Clinical Problem
Pathophysiology and the Effect of Therapy
Clinical Evidence
Clinical Use
Adverse Effects
Areas of Uncertainty
Guidelines
Recommendations
Source Information
From the Division of Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Boston.
Address reprint requests to Dr. Orgill at the Division of Plastic and Reconstructive Surgery, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115, or at dorgill@partners.org.
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