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Volume 360:933-935 February 26, 2009 Number 9
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Genetically Elevated C-Reactive Protein and Vascular Disease

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by Zacho, J.
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To the Editor: Zacho and colleagues (Oct. 30 issue)1 provide considerable support for other studies2 that suggest that since polymorphisms in the C-reactive protein (CRP) gene are not associated with ischemic heart disease, CRP itself is not causally associated with ischemic heart disease. We agree that "the meaning of theoretically predicted hazard ratios . . . may be somewhat difficult to understand." Rather than comparing observed and predicted associations between the genotype and ischemic heart disease for each genotype, we suggest that the causal effect of CRP on ischemic heart disease should be estimated on the basis of the associations . . . [Full Text of this Article]



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