To the Editor: In the Normoglycemia in Intensive Care Evaluation–SurvivalUsing Glucose Algorithm Regulation (NICE-SUGAR) study (ClinicalTrials.govnumber, NCT00220987
[ClinicalTrials.gov]
), reported by Finfer et al. (March 26 issue),1intensive glucose control increased mortality. These findingsare clearly at variance with the decreased mortality that wereported from our center in Leuven, Belgium.2,3,4 Finfer etal. do not address several possible explanations for this discrepancy.
First, normoglycemia (blood glucose level, <110 mg per deciliter[6.1 mmol per liter]) was compared with distinct blood glucosecontrol with target ranges of 140 to 180 mg per deciliter (7.8to 10.0 mmol per liter) . . . [Full Text of this Article]
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