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Correspondence
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Volume 361:1023-1024 September 3, 2009 Number 10
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Chemotherapy in Older Women with Breast Cancer

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by Muss, H. B.
To the Editor: Muss et al. (May 14 issue)1 report that standard adjuvant chemotherapy is superior to capecitabine in older women with early-stage breast cancer. However, the authors neglect to mention that adjuvant radiotherapy in patients with positive axillary nodes affects relapse-free survival.2,3

The use of chest-wall and regional lymph-node irradiation after mastectomy and chemotherapy is recommended in women with four or more positive axillary lymph nodes, and it is recommended for strong consideration in women with one to three positive axillary lymph nodes.3,4 Prophylactic chest-wall irradiation in these patients substantially reduces the risk of local recurrence.5


Yue-Can Zeng, M.D.
. . . [Full Text of this Article]



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