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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.
A healthy 76-year-old woman presents as a new patient for primary care. She reports having one daily bowel movement and no rectal bleeding. She has no family history of colorectal cancer. She reports having negative stool card tests during gynecologic examinations, most recently at 65 years of age. Would you advise this patient to undergo colon-cancer screening, and if so, what test
The Clinical Problem
Strategies and Evidence
Identification of High-Risk Persons
Prevention Strategies for Average-Risk Persons
Screening Tests and Strategies
Fecal Screening Tests
Structural Examinations of the Colon
Radiographic Studies
Sigmoidoscopy
Colonoscopy
Risks of Screening
Areas of Uncertainty
Guidelines
Conclusions and Recommendations
Source Information
From the Division of Gastroenterology and Hepatology, Oregon Health and Science University, Portland.
An audio version of this article is available at NEJM.org.
Address reprint requests to Dr. Lieberman at the Department of Medicine, Oregon Health and Science University, Mail Code L461, 3181 S.W. Sam Jackson Park Rd., Portland, OR 97239, or at lieberma@ohsu.edu.
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