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Previous Volume 361:1213-1214 September 17, 2009 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Brent (May 21 issue)¹ discusses the osmolal gap in the management of ethylene glycol and methanol poisoning. Although a high anion gap is characteristic and an elevated osmolal gap is a useful indicator of toxic alcohols in blood, an understanding of their temporal relationship is essential to avoid mismanagement of these conditions. The development of osmolal and anion gaps varies as a function of time from ingestion. As metabolism progresses, increasing amounts of these alcohols are converted to their metabolites. The contribution of the parent compounds to the osmolal gap decreases, whereas the contribution of the metabolites . . . [Full Text of this Article]

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