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Previous Volume 361:1310-1312 September 24, 2009 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Pui and colleagues (June 25 issue)¹ report a high likelihood of event-free and overall survival among children with acute lymphoblastic leukemia (ALL) treated with an intensive regimen of intrathecal chemotherapy and systemic drugs that penetrate the central nervous system (CNS). Their goal was to eliminate cranial irradiation and its late toxic effects. Most other trials of treatment for childhood ALL already treat the majority of patients (80% or more) without cranial irradiation, with similarly favorable results. Indeed, only 14% of patients in the study reported on by Pui et al. would have received cranial irradiation in previous . . . [Full Text of this Article]

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