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Previous Volume 361:1376-1385 October 1, 2009 Number 14 Next

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An estimated 25 to 65% of pregnant women in the United States have genital infection with herpes simplex virus type 1 (HSV-1) or HSV type 2 (HSV-2).¹ Neonatal HSV infection, defined as infection in a newborn within 28 days after birth, is an especially devastating consequence of the epidemic of genital herpes. Untreated neonatal HSV infection is associated with only a 40% survival rate, and even with the early initiation of high-dose intravenous acyclovir therapy, it results in considerable disability among survivors.

On the basis of hospital discharge data, the frequency of neonatal HSV infection in the United States varies . . . [Full Text of this Article]

Pathophysiology

Diagnosis

Manifestations of Neonatal HSV Infection

Treatment of Neonatal HSV Infection

Prevention of Neonatal HSV Infection

Reducing Acquisition of HSV-1 and HSV-2 in Late Pregnancy

Reducing Neonatal Herpes in HSV-2–Seropositive Women

Identifying Infants at Risk

Source Information

From the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, (L.C., A.W.); and the Departments of Medicine (L.C., A.W.), Laboratory Medicine (L.C., A.W.), and Epidemiology (A.W.), University of Washington — both in Seattle.

Address reprint requests to Dr. Corey at the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, LE-500, Seattle, WA 98109, or at lcorey@u.washington.edu.

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