DNA Damage, Aging, and Cancer

doi:10.1056/NEJMra0804615

A correction has been published: N Engl J Med 2009;361(19):1914.

Volume 361:1475-1485		October 8, 2009		Number 15

DNA Damage, Aging, and Cancer

Jan H.J. Hoeijmakers, Ph.D.

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PubMed Citation

DNA damage has emerged as a major culprit in cancer and manydiseases related to aging. The stability of the genome is supportedby an intricate machinery of repair, damage tolerance, and checkpointpathways that counteracts DNA damage. In addition, DNA damageand other stresses can trigger a highly conserved, anticancer,antiaging survival response that suppresses metabolism and growthand boosts defenses that maintain the integrity of the cell.Induction of the survival response may allow interventions thatimprove health and extend the life span. Recently, the firstcandidate for such interventions, rapamycin (also known as sirolimus),has been identified.¹ . . . [Full Text of this Article]

DNA Damage and Aging

The Magnitude of DNA Damage

Genome Maintenance

The DNA-Repair Toolbox

Diseases of Nucleotide-Excision Repair

Xeroderma Pigmentosum

Cockayne's Syndrome

Trichothiodystrophy

Progeria, Aging, and the Survival Response

DNA Damage and DNA Maintenance in Cancer

Compromised Genome Maintenance and Cancer Therapy

Summary and Future Perspectives

Source Information

From the Department of Genetics, Cancer Genomics Center, Erasmus University Medical Center, Rotterdam, the Netherlands.

This article (10.1056/NEJMra0804615) was updated on November 4, 2009, at NEJM.org.

Address reprint requests to Dr. Hoeijmakers at the Department of Genetics, Cancer Genomics Center, Erasmus University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, the Netherlands, or at j.hoeijmakers@erasmusmc.nl.