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Previous Volume 361:1500-1501 October 8, 2009 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The discovery of RNA interference triggered a "silent" revolution that overturned our understanding of how gene expression is regulated.¹ The previous model was that gene expression was activated during transcription, the process of copying the DNA sequence into RNA, when transcription factor proteins bind to promoter sequences in DNA upstream of the gene's coding sequence. Now it is clear that an additional important mechanism of gene regulation occurs at the next stage of translating the messenger RNA (mRNA) into protein. Small, noncoding RNAs that have a stem loop structure, called microRNAs, regulate translation by binding to partially complementary sequences of . . . [Full Text of this Article]

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From the Immune Disease Institute and the Program in Cellular and Molecular Medicine at Children's Hospital Boston and the Department of Pediatrics, Harvard Medical School, Boston.

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