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Previous Volume 361:1505-1506 October 8, 2009 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Multiple sclerosis has been classified as a disorder affecting the white matter of the central nervous system. Foci of demyelination, scattered throughout the white matter, are conspicuous on gross postmortem inspection of the brain. Such findings have led to the perception that multiple sclerosis is a demyelinating disease affecting the white matter. In the past 25 years, many magnetic resonance imaging (MRI) studies have shown lesions scattered through the white matter. These lesions develop at disease onset and accumulate over time. However, white-matter lesions, quantified by various MRI techniques, correlate weakly with neurologic disability.

This paradox may be at least . . . [Full Text of this Article]

Source Information

From the Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute (R.A.R.), and the Department of Neurosciences, Lerner Research Institute (B.D.T.), Cleveland Clinic, Cleveland.

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