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Clinical Implications of Basic Research
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Volume 361:1904-1906 November 5, 2009 Number 19
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The Microcytic Red Cell and the Anemia of Inflammation
Siobán B. Keel, M.D., and Janis L. Abkowitz, M.D.

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When evaluating a patient with anemia in whom inflammation is present, the physician typically observes the mean corpuscular volume and then requests biochemical analyses to determine the serum iron and ferritin levels, total iron-binding capacity, and transferrin saturation (calculated as serum iron level divided by the total iron-binding capacity, expressed as a percentage). If the transferrin saturation is less than 10% and the ferritin level is less than 30 ng per milliliter, iron deficiency is diagnosed as the cause of the anemia. If the transferrin saturation is low (15%) and the ferritin level is high (>200 ng per milliliter), inflammatory . . . [Full Text of this Article]


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From the Division of Hematology, University of Washington, Seattle.




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