Geographic Dependence, Surveillance, and Origins of the 2009 Influenza A (H1N1) Virus

doi:10.1056/NEJMp0904572

Volume 361:115-119		July 9, 2009		Number 2

Geographic Dependence, Surveillance, and Origins of the 2009 Influenza A (H1N1) Virus

Vladimir Trifonov, Ph.D., Hossein Khiabanian, Ph.D., and Raul Rabadan, Ph.D.

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PubMed Citation

In April 2009, a new strain of human H1N1 influenza A viruswas identified in Mexico. According to the World Health Organization(www.who.int/csr/don/2009_05_25), as of May 25, 2009, the virushad spread to 43 countries, with 12,515 reported cases and 91associated deaths, and it has been assessed as having pandemicpotential.¹

Genomic analysis of the 2009 influenza A (H1N1) virus in humansindicates that it is closely related to common reassortant swineinfluenza A viruses isolated in North America, Europe, and Asia(Figure 1).²^,³^,⁴ The segments coding for the polymerase complex,hemagglutinin, nuclear protein, and . . . [Full Text of this Article]

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From the Department of Biomedical Informatics, Center for Computational Biology and Bioinformatics, Columbia University College of Physicians and Surgeons, New York.

This article (10.1056/NEJMp0904572) was published on May 27, 2009, at NEJM.org.