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Previous Volume 361:170-177 July 9, 2009 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.

A 56-year-old woman presents to her physician, requesting screening for ovarian cancer. She reports the recent death of a friend from ovarian cancer at the age of 65 years. The patient has no family history of ovarian or breast cancer. The physical examination, including pelvic and rectal examination, is normal. Should the physician recommend screening for ovarian cancer?

The Clinical Problem

Ovarian cancer accounts for . . . [Full Text of this Article]

Strategies and Evidence

Routine Screening

Ultrasonography

Tumor Markers

            CA-125

            Other Markers

Ongoing Screening Trials

Screening for High-Risk Women

Areas of Uncertainty

Guidelines

Conclusions and Recommendations

Source Information

From the Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill.

An audio version of this article is available at NEJM.org.

Address reprint requests to Dr. Clarke-Pearson at the Department of Obstetrics and Gynecology, Old Clinic Rm. 3009, CB# 7570, University of North Carolina, Chapel Hill, NC 27599, or at danielcp@med.unc.edu

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