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Volume 361:206-208 July 9, 2009 Number 2
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Esomeprazole for Asthma

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 by The American Lung Association Asthma Clinical Research Centers
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To the Editor: In their article on the use of esomeprazole in patients with poorly controlled asthma (April 9 issue),1 Mastronarde et al. conclude that treatment with proton-pump inhibitors does not improve asthma control in such patients. They also state that despite a high prevalence of asymptomatic gastroesophageal reflux in these patients, the condition is not a likely cause of poorly controlled asthma. In clinical practice, esophageal reflux is usually confirmed by ambulatory pH monitoring with the use of an instrument that assesses reflux episodes in patients with acid reflux but not in those with nonacid reflux.2,3 In addition, acid-reflux . . . [Full Text of this Article]




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