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Volume 361:211 July 9, 2009 Number 2
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Genetics of Type 1A Diabetes

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by Concannon, P.
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To the Editor: In their review article on the genetics of type 1A diabetes, Concannon et al. (April 16 issue),1 citing Aly et al.,2 state that the disorder develops in approximately 1 of 20 persons with high-risk HLA haplotypes. Such data refer to siblings of persons with type 1A diabetes. The real challenge is to identify the development of type 1A diabetes in the general population. A study involving 1031 healthy Sardinian schoolchildren (age range, 10 to 16 years)3 showed that after a follow-up period of 2.7 to 8.2 years, type 1A diabetes developed in 1 of 8 children who . . . [Full Text of this Article]



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