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Volume 361:415-421 July 23, 2009 Number 4
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The Importance of Brown Adipose Tissue

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To the Editor: In the April 9 issue, van Marken Lichtenbelt et al.,1 Cypess et al.,2 and Virtanen et al.3 report on functioning supraclavicular brown adipose tissue in adult humans. Van Marken Lichtenbelt et al. conclude that brown-adipose-tissue activity induced by exposure to cold is impaired in overweight healthy subjects, and Cypess et al., using epidemiologic-association techniques, conclude that older subjects and those with a higher body-mass index (BMI) have less brown adipose tissue. It is suggested that obesity is associated with reduced brown-adipose-tissue function or activity. However, disseminated brown adipocytes4 within the large subcutaneous adipose-tissue mass may cumulatively represent . . . [Full Text of this Article]




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