FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Published at www.nejm.org October 15, 2008 (10.1056/NEJMe0807576)

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Bouzigon, E. PubMed Citation

It has long been established that many common diseases are the result of interactions between genetic susceptibility and environmental exposure. The identification of genetic variants that underlie susceptibility to diseases and alter the expression or function of proteins (either familiar or novel) can implicate the protein in question in the pathogenesis of the disease. This not only increases the understanding of disease pathophysiology but also can lead to the development of new therapeutic agents. It is this hope that has spurred the search for genetic variants underlying common diseases during the past quarter century.

The advances of the Human Genome . . . [Full Text of this Article]

Source Information

From the Divisions of Infection, Inflammation and Repair and of Human Genetics, School of Medicine, University of Southampton, Southampton, United Kingdom (J.W.H.); and the Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (G.H.K.).

This article (10.1056/NEJMe0807576) was published at www.nejm.org on October 15, 2008. It will appear in the November 6 issue of the Journal.

HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  TERMS OF USE  |  HELP  |  beta.nejm.org Comments and questions? Please contact us. The New England Journal of Medicine is owned, published, and copyrighted © 2009 Massachusetts Medical Society. All rights reserved.