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Editorial
Published at www.nejm.org October 30, 2009 (10.1056/NEJMe0909664)

Treatment of Anemia in Chronic Kidney Disease — Strategies Based on Evidence
Philip A. Marsden, M.D.

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Anemia associated with chronic kidney disease and end-stage renal disease is due, in large part, to reduced production of renal erythropoietin and abnormalities in extracellular-fluid volume homeostasis.1 Moreover, anemia and disordered salt and water handling, which usually manifest as hypertension, predict cardiovascular and renal outcomes in patients with chronic kidney disease.2 The combination of early recognition and treatment to reduce increased blood pressure is known to improve outcomes. Thus, it is surprising, since highly effective therapies for anemia have been available for more than 20 years,3 that so little is known about whether the treatment of anemia has similar salutary . . . [Full Text of this Article]


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From the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital; and the University of Toronto — both in Toronto.

This article (10.1056/NEJMe0909664) was published on October 30, 2009, at NEJM.org.




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