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STATISTICS AND MEDICINE Published at www.nejm.org July 18, 2007 (10.1056/NEJMp078120)

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The past 3 months have seen the publication of a series of studies examining the inherited genetic underpinnings of common diseases such as prostate cancer, breast cancer, diabetes, and in this issue of the Journal, coronary artery disease (reported by Samani et al.). These genomewide association studies have been able to examine interpatient differences in inherited genetic variability at an unprecedented level of resolution, thanks to the development of microarrays, or chips, capable of assessing more than 500,000 single-nucleotide polymorphisms (SNPs) in a single sample. This "SNP-chip" technology capitalizes on a catalogue of common human genetic variations that is provided . . . [Full Text of this Article]

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Dr. Hunter is a professor of epidemiology at the Harvard School of Public Health, Boston, a statistical consultant to the Journal, and codirector of the National Cancer Institute's Cancer Genetic Markers of Susceptibility project. Dr. Kraft is an assistant professor of epidemiology and biostatistics at the Harvard School of Public Health, Boston.

This article (10.1056/NEJMp078120) was published at www.nejm.org on July 18, 2007. It will appear in the August 2 issue of the Journal.

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