FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Published at www.nejm.org June 6, 2008 (10.1056/NEJMp0803740)

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by The Action to Control Cardiovascular Risk in Diabetes Study Group Related Article by The ADVANCE Collaborative Group PubMed Citation

Simple approaches to patient care are better — except when they are not. Recent clinical studies are leading to a reexamination of the paradigm whereby efforts to prevent vascular disease focus on the achievement of particular levels of risk factors such as low-density lipoprotein (LDL) cholesterol, systolic blood pressure, and glycated hemoglobin. Although these factors and their levels are important determinants of the development and progression of vascular disease, it is increasingly apparent that the specific strategies used to modify them make a critical difference in patient outcomes. This insight has implications for clinical practice, performance measurement, and regulatory requirements.

. . . [Full Text of this Article]

Source Information

Dr. Krumholz is a professor of medicine at Yale University School of Medicine and director of the Center for Outcomes Research and Evaluation at Yale–New Haven Hospital — both in New Haven, CT. Dr. Lee is network president of Partners HealthCare System in Boston and an associate editor of the Journal.

This article (10.1056/NEJMp0803740) was published at www.nejm.org on June 6, 2008. It will appear in the June 12 issue of the Journal.

This article has been cited by other articles:

• Potenza, M. A., Gagliardi, S., De Benedictis, L., Zigrino, A., Tiravanti, E., Colantuono, G., Federici, A., Lorusso, L., Benagiano, V., Quon, M. J., Montagnani, M. (2009). Treatment of spontaneously hypertensive rats with rosiglitazone ameliorates cardiovascular pathophysiology via antioxidant mechanisms in the vasculature. Am. J. Physiol. Endocrinol. Metab. 297: E685-E694 [Abstract] [Full Text]  
• Dhar, G. C. (2009). Intensive glycemic control: Implications of the ACCORD, ADVANCE, and VADT trials for family physicians. cfp 55: 803-804 [Full Text]  
• The NICE-SUGAR Study Investigators, (2009). Intensive versus Conventional Glucose Control in Critically Ill Patients. NEJM 360: 1283-1297 [Abstract] [Full Text]  
• Kassabian, S. G. (2009). Hemoglobin A1c Testing, Board-Recertification Scores, and Treatment Outcomes. Arch Intern Med 169: 417-417 [Full Text]