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Previous Volume 330:1689 June 9, 1994 Number 23 Next

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To the Editor: During further analysis of the data used in our study of single-drug therapy for hypertension in men (April 1, 1993, issue),¹ we discovered two errors in the computer program; these errors affected the results that we reported in Figures 2 and 3 of the article. One error permitted a small group of patients who had not completed one year of maintenance therapy to be excluded from the analysis, even though we had planned an intention-to-treat analysis. The second error was due to an unrecognized deletion of an entire line of code that provided the definition of treatment success. This error also led to an underestimation of the percentage of successes. Correction of the error did not result in an even increase in this percentage across treatment groups, so that there were some changes in the order of the drugs.

It is important to note that the basic conclusion of the study was not affected -- that is, race and age have an important effect on the response to single-drug therapy for hypertension in men. Table 1 shows the correct values for Figures 2 and 3.

View this table: [in this window] [in a new window]   Table 1. Corrected Values for Figures 2 and 3 of Materson et al.

 

Barry J. Materson, M.D., M.B.A.
Department of Veterans Affairs Medical Center
Miami, FL 33125

Domenic J. Reda, M.S.
Department of Veterans Affairs Medical Center
Hines, IL 60141

References

1. Materson BJ, Reda DJ, Cushman WC, et al. Single-drug therapy for hypertension in men -- a comparison of six antihypertensive agents with placebo. N Engl J Med 1993;328:914-921. [Free Full Text]

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