Figure 3. In Situ Hybridization with the EBER Probe of a Lung-Tumor Specimen from Patient 2 (x128).

There is strong, uniformly positive staining of nuclei in tumor cells (reddish-brown areas) but no staining of nuclei in compressed normal stroma (lower right). The inset shows the results of immunohistochemical analysis of tissue from a native-colon tumor in Patient 3 with the use of antibody against muscle-specific actin, followed by in situ hybridization with the EBER probe. The tumor cells are positive for both actin (brown areas) and EBER RNA (blue-black areas) (x400).

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